Cell Imaging Service—Molecular Devices ImageXpress Micro

As cell research advances, so does the need for cell imaging technology. Today's researchers need a continuous flow of dynamic, long-term experiments on cell migration, interactions, and responses to environmental disturbances that cannot be met by conventional microscopes that can only observe stationary cells. Creative Bioarray' Molecular Devices ImageXpress Micro-based live cell imaging technology can meet your stringent experimental needs.

Name of the Instrument/Platform

Molecular Devices ImageXpress Micro

Introduction

The Molecular Devices ImageXpress Micro is a high-speed imaging solution for fluorescence studies of cells, typically in a microtiter plate format. The imaging is uniform (< 5% CV across a plate) with high-reliability and ease-of-use. A laser-autofocus allows reliable imaging of transwell inserts, as well as various thickness microtiter plates. The dynamic range is exceptional (3-log range). Our installation has almost all the accessories offered by Molecular Devices. Full environmental control allows imaging living cells, as well as fixed. An automated single-channel pipettor (fluidics option) can use two microtiter plates (96-or 384-well) as the source for compound addition or media exchange. For analysis, we have over a dozen modules to analyze plate experiments, including live/dead cell counting, neurite outgrowth, subcellular translocation and mitotic index. Specifications: 1. Lumencor SOLA solid-state fluorescence light source 2. High-resolution scientific CMOS (sCMOS) camera for fast imaging 3. Full environmental control (heating, cooling, CO₂, humidity). Allow h to equilibrate when changing temperature. 4. Objectives: 4×/0.2 PlanApo (20mm wd), 10×/0.3 PlanFluor, 20×/0.45 PlanFluor, 40×/0.95 PlanApo (0.16-0.25 mm wd, corr coll), 60×/0.95 PlanApo (0.11-0.21 mm wd), 100×/0.85 PlanEpi (0-0.7 mm wd, corr coll) 5. Filter sets (Semrock): DAPI, CFP, GFP, YFP, Rhodamine/TRITC, Texas Red, Cy3, Cy5, Colorimetric (Red/Green/Blue) 6. Analysis Modules: Angiogenesis, Cell-cycle, Cell Health, Cell Proliferation, Count Nuclei, Granulariy, Live/Dead, Mitotic Index, Monopole Detection, Multiwavelength Cell-scoring, Neurite Outgrowth, Micronuclei, Transfluor, Translocation, Multi-wavelength Translocation (subcellular) 7. Digital confocal option available in software

Summary

Model & Grant Information 1.Molecular Devices ImageXpress Micro XLS Widefield high-Content Analysis System 2.MetaXpress high-content analysis software (multiple licenses) 3.Includes microtiter plate robot (54 plates) and pipet fluidics accessories

Feature Highlights

Applications

1. High-speed, high-resolution imaging (> 6000 images in 30 min, 384-well plate, 4 positions/well, 4 colors) 2. Fast large-area imaging (slide-mounted tissue slices) 3. Drug/agonist screening

Technical Capabilities

The Molecular Devices ImageXpress Micro-based cell imaging service offered by Creative Bioarray supports high-resolution fluorescence and brightfield image acquisition, enabling real-time recording of data over hours, days, or weeks. If you need our help, please contact us directly.